儿童早期的呼吸系统问题和摩尔切割器低矿化:系统审查和元分析
Ronney Brandão Osterno1, Lara Carvalho Costa2, Francisco Wilker Mustafa Gomes Muniz3
1Department of Pathology and Dental Clinic, Federal University of Piauí, Teresina, Piauí, Brazil.
Odontology
|February 10, 2026
概括
早期儿童的呼吸系统问题,如喘和肺炎,可能与摩尔切割器低矿化 (MIH) 有关. 然而,目前的证据非常有限和不一致,阻止关于因果关系的最终结论.
科学领域:
- 儿科牙科 儿科牙科
- 呼吸系统医学 呼吸系统医学
- 流行病学 流行病学
背景情况:
- 摩拉切割器低矿化 (MIH) 是一种质量缺陷的牙,影响永久的第一个摩拉和切割器.
- 儿童早期的呼吸系统疾病很常见,它们对牙发育的潜在影响需要调查.
研究的目的:
- 系统地审查和评估科学文献,以了解儿童早期呼吸系统问题与摩尔切割器低矿化 (MIH) 之间的关联.
主要方法:
- 在遵守PRISMA指南的情况下,对观察性研究进行了系统审查和元分析.
- 在多个数据库 (MEDLINE-PubMed,Scopus,EMBASE,科学网,谷歌学者,OpenGrey) 中进行了搜索.
- 偏差风险和证据确定性分别使用JBI,纽卡斯尔-太华尺度和GRADE框架进行评估.
主要成果:
- 12项研究被纳入了4项元分析,定量综合仅限于喘和肺炎.
- 在调整后的分析中,喘与MIH没有显著的关联 (OR1.93),具有很高的异质性.
- 肺炎显示出与MIH的整体积极关联 (OR 3.33),但所有发现的证据确定性非常低.
结论:
- 虽然早期的呼吸道疾病可能与MIH有关,但目前的证据确定性非常低,且不一致.
- 这些发现不允许对儿童呼吸问题和MIH之间的关系进行因果推断.
- 需要进一步进行高质量的研究,以澄清任何潜在的联系.
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