单个唾液样本以模型为依据,为治疗多药耐药结核病的利沃弗洛克萨辛精确剂量
Thi A Nguyen1,2,3, Tri P Nguyen4, Anh T Nguyen5,6,7
1Faculty of Medicine and Health, Sydney Pharmacy School, The University of Sydney, Pharmacy Building (A15), Sydney, NSW, 2006, Australia.
非侵入性唾液采样可以有效地监测levofloxacin水平,用于治疗多药耐药结核病 (MDR-TB). 一个2小时的唾液样本可以准确预测药物暴露,简化治疗药物监测 (TDM).
科学领域:
- 药理动力学 药理动力学
- 结核病的治疗方法
- 药物监测 药物监测 药物监测
背景情况:
- 列沃素对多药耐药结核病 (MDR-TB) 是至关重要的,但具有很高的药物动力学变异性.
- 通过治疗药物监测 (TDM) 优化勒沃素暴露对于治疗成功至关重要.
- 传统的TDM依赖于侵入性血液采样,这带来了可行性挑战.
研究的目的:
- 使用血和唾液数据,开发一个人群药理动力学 (popPK) 模型来测试勒沃素.
- 评估基于唾液的有限采样策略对利沃素TDM的有用性.
- 在临床实践中支持基于模型的TDM用于levofloxacin.
主要方法:
- 从接受口服levofloxacin的成年患者收集配对的血和唾液样本.
- 使用NONMEM开发了血和唾液popPK模型,包括共变量分析.
- 用贝叶斯估计和模拟来预测曲线下的血面积 (AUC24) 的评估唾液采样策略.
主要成果:
- 一个带有唾液生物分区的单个分区模型准确地描述了levofloxacin的药理动力学.
- 基于唾液的采样策略,包括单个2小时的样本,在可接受的范围内准确预测了血AUC24.
- 没有发现影响勒沃素药理动学的显著共变量.
结论:
- 开发的popPK模型允许从有限的唾液样本可靠地估计levofloxacin暴露.
- 一个剂量后2小时的唾液样本可以支持MDR-TB护理中的基于模型的levofloxacin TDM.
- 这种非侵入性方法提高了TDM的可行性,特别是当血液采样具有挑战性时.
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