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Updated: Feb 12, 2026

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

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调节嗅觉受体反应的RIC8B变体的结构和功能分析

Rina Shirai1,2, Shuji Hinuma1, Shun'ichi Kuroda1,2

  • 1SANKEN, The University of Osaka, 8-1 Mihogaoka, Ibaraki, Osaka, Japan.

Bioscience, biotechnology, and biochemistry
|February 10, 2026
PubMed
概括

对胆酶8B (RIC8B) 抑制剂4 (v4) 变异的耐药性缺少一个关键域,破坏Gαs结合并抑制嗅觉受体反应. 这表明v4通过不当折叠Gαs.可能会产生主导负效应.

关键词:
这是一种G蛋白质蛋白质,G蛋白质蛋白质.在RIC8B中,我们可以使用RIC8B.cAMPP 这是一个很棒的平台.陪伴者是一个陪伴者.嗅觉受体是一种嗅觉受体.

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