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相关概念视频

Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...

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相关实验视频

Updated: Jul 1, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

使用聚合物学习大自然的装配语言.

Oliver Xie1, Alexander E Cohen1, Martin Z Bazant1

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.

Proceedings of the National Academy of Sciences of the United States of America
|February 10, 2026
PubMed
概括
此摘要是机器生成的。

本研究介绍了一个计算算法,用于反向设计的块共聚合物. 它可以通过学习针对目标结构的分子序列来编程自我组装,克服设计复杂性.

关键词:
区块共聚物的区块共聚物.设计的反向设计.自动组装的自动组装机

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Polymer Microarrays for High Throughput Discovery of Biomaterials
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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

相关实验视频

Last Updated: Jul 1, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Polymer Microarrays for High Throughput Discovery of Biomaterials
13:37

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

科学领域:

  • 软物质物理学 软物质物理学
  • 材料科学 材料科学 材料科学
  • 计算化学的计算化学

背景情况:

  • 物质的自我组装成有序的结构在自然和工程中至关重要.
  • 通过分子结构控制宏观材料的特性是一个重大的科学挑战.
  • 块共聚合物是研究自组装和反向设计的关键模型系统.

研究的目的:

  • 开发一个计算算法,用于反向设计的区块共聚合物序列.
  • 为了能够预测产生特定自组装结构的分子序列.
  • 为了应对复杂的共聚合物设计中广泛的序列可能性的挑战.

主要方法:

  • 为自相一致的场理论 (SCFT) 方程开发一个附加的解决方案.
  • 整合自动区分,以实现高效的计算.
  • 使用热力学模型来指导反向设计过程.

主要成果:

  • 该算法成功逆向设计了聚合物序列,以实现所需的平衡结构.
  • 证明了调节不良块相互作用以稳定复杂形态的能力.
  • 克服了设计复杂的共聚合物序列的组合挑战.

结论:

  • 开发的算法提供了一种在分子水平上编程自我组装的方法.
  • 这项工作为其他软物质系统的计算反向设计开辟了可能性.
  • 通过精确的分子工程,提高了通过精确分子工程控制材料特性的能力.