基因饮食和微生物群-肠-大脑轴在耐药中的相互作用:系统性审查
Thiago G R Barros1, João V C Modesto2, Michelle C A Paula1
1Integrated Laboratory of Pathology Research, Department of Pathology, School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, MG, 36038-330, Brazil.
Nutrition reviews
|February 10, 2026
概括
性饮食 (KD) 在耐药性 (DRE) 中改变了微生物群-肠-大脑轴 (MGBA). 特定的MGBA变化与控制相关,但由于研究的局限性,需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢过程中的代谢.
背景情况:
- 性饮食 (KD) 是一种被公认的治疗药物耐药性 (DRE) 的疗法.
- 新兴研究表明,KD影响微生物群-肠-大脑轴 (MGBA),可能影响治疗结果.
研究的目的:
- 系统地审查KD后DRE患者的MGBA变化.
- 检查MGBA变化与DRE中KD的临床反应之间的关联.
主要方法:
- 对主要科学数据库进行了全面的系统搜索.
- 分析了来自七项涉及93名KDDDRE患者的纵向研究的数据.
- 评估了偏差风险,并以叙事方式综合了发现.
主要成果:
- 结核病诱导了肠道微生物群组成的变化 (例如,改变的Firmicutes,Actinobacteria,Bacteroidetes).
- 代谢途径转向脂肪酸代谢,SCFA和炎症标志物减少.
- 特定的微生物种群和代谢物与改善或恶化控制有关.
结论:
- 在DRE患者中,KD诱导了一致的MGBA变化.
- 某些MGBA概况与控制相关,尽管证据因研究质量和样本大小而有限.
- 需要对更大,更多样化的队伍进行进一步的研究,以探索对DRE.的微生物群信息治疗方法.
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