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Updated: Feb 12, 2026

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阴影衍生的小细胞外囊泡携带致病性RNA,在皮质梗塞后驱动远程损伤

Die Deng1,2,3, Yousheng Wu1,2,3,4, Panwen Wu1,2,3

  • 1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Neurology and Stroke Center, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.

Brain : a journal of neurology
|February 10, 2026
PubMed
概括

来自缺血性中风阴影的小细胞外囊 (SEV) 将致病性RNA,如CircOGDH,传递到遥远的大脑区域. 这种EV介导的RNA传输会导致二次神经元和突触损伤,提供新的治疗点.

关键词:
由大脑衍生的细胞外囊泡.皮质othalamic通道的路径.缺血性中风 中风没有编码的RNA.半阴影 半阴影

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