西尼罗河病毒在印度尼西亚传播的血清学证据:对未被认可的弗拉维病毒威胁的初步见解
Yora Permata Dewi1, Rintis Noviyanti2, Leily Trianty2
1Exeins Health Initiative, Jakarta, Indonesia.
PloS one
|February 10, 2026
概括
西尼罗河病毒 (WNV) 可能在印度尼西亚未被检测到. 一项血清检测在无症状个体中发现了WNV反应性IgM,这表明静默的WNV循环需要进一步调查.
科学领域:
- 医学昆虫学 医学昆虫学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 西尼罗河病毒 (WNV) 是一种蚊子传播的病毒,通常在鸟蚊周期中维持.
- 虽然不被认为是特有,但印尼的WNV存在被零星发现所暗示.
- 了解WNV的传播对于公共卫生监测至关重要.
研究的目的:
- 调查印度尼西亚西尼罗河病毒 (WNV) 潜在的未被确认的传播情况.
- 确定巴布亚和加利曼坦的非发烧个体中WNV感染的血清流行率.
- 评估由于与其他病毒的交叉反应性导致的诊断挑战.
主要方法:
- 对569个存档的血清和血样本进行横截面血清检测 (2021-2023年).
- 使用商业WNV IgM酶链接免疫吸收试验 (ELISA) 进行查.
- 用IgM ELISA测试进行WNV,登革热病毒 (DENV),日本脑炎病毒 (JEV) 和寨卡病毒 (ZIKV) 的确认测试.
主要成果:
- 在1.58%的样本中检测到初始WNVIgM反应性;1.23%是模两可的.
- 确认的WNV IgM血清流行率为0.35%,其中1.76%显示对其他黄病毒的交叉反应性.
- 在北加里曼丹和巴布亚地区发现了阳性病例.
结论:
- 在无症状个体中检测到WNV反应性IgM表明印尼可能存在静默WNV循环.
- 诊断交叉反应性和IgM持久性需要进一步研究.
- 建议使用分子工具,PRNT,IgG测试和昆虫学数据来澄清WNV流行病学和监测.
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