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对帕金森病的运动和非运动症状进行个性化的富含植物,时间限制的营养干预:随机对照试验
Beyza Tağraf1, Özden Erkan Oğul1, Deniz Yerlikaya2
1Neuroscience Research Center, Research Institute for Health Sciences and Technologies, SABITA, Istanbul Medipol University, Istanbul, Turkey.
Journal of Parkinson's disease
|February 10, 2026
概括
一种个性化性饮食 (Ketoflex 12/3) 改善了帕金森病的运动和非运动症状. 这种营养干预,结合标准护理,在UPDRS-III分数和其他关键健康标志物上显示出显著的好处.
科学领域:
- 神经学 神经学
- 营养科学 营养科学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 帕金森病 (PD) 是一种进展性神经退行性疾病,影响运动和非运动功能.
- 目前的治疗方法可以缓解症状,但不能阻止疾病的进展.
- 正在探索个性化的方法,以更有效地管理PD症状.
研究的目的:
- 为了研究个性化的Ketoflex 12/3营养方案与帕金森病的标准医疗护理相结合的疗效.
- 评估这种干预措施对PD患者的运动和非运动症状的影响.
- 评估干预对不同患者生物型 (炎症性,糖毒性,有毒性,血管性) 的影响.
主要方法:
- 一项随机对照试验,涉及40名帕金森病患者.
- 参与者被分配到干预组 (Ketoflex 12/3饮食,间歇性禁食) 或对照组.
- 评估包括统一帕金森病评分表第三部分 (UPDRS-III),斯塔克斯坦冷漠度表,ADL/IADL和布里斯托尔便尺度超过六个月.
主要成果:
- 与对照组相比,干预组在运动症状 (UPDRS-III) 中表现出明显更大的改善 (-11.0 vs +2.1 分; p < 0.001).
- 在次要结局方面也观察到显著的改善:冷漠,日常生活活动 (ADL/IADL) 和胃肠功能.
- 炎症表型个体在改善ADL和降低UPDRS-III得分之间显示出显著的相关性.
结论:
- 个性化的营养方法,如Ketoflex 12/3协议,可以有效地改善帕金森病的运动和非运动症状.
- 这些发现支持量身定制的饮食干预作为PD管理的辅助疗法的潜力.
- 进一步的大规模,多中心试验和更长的随访是有必要的,以证实这些结果.
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