尿道微生物组和代谢组区分了膀过活和生理状态,并反映了最近的抗生素使用和治疗反应
Glenn T Werneburg1,2, Michael D Gross1, Daniel R Hettel1
1Department of Urology, Glickman Urological Institute, Cleveland Clinic, Cleveland, OH, USA.
The Journal of urology
|February 10, 2026
概括
尿道微生物组在有过度活跃膀 (OAB) 和没有过活跃膀 (OAB) 的个体之间有所不同. 在OAB患者中,特定的细菌系如Escherichia和Enterococcus更为丰富,为潜在的微生物组向疗法提供了信息.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
背景情况:
- 人们越来越认识到尿路微生物组在健康和疾病中的作用.
- 过度活性膀 (OAB) 是一种影响数百万人的疾病,其潜在的病理生理学尚未完全理解.
- 在OAB中描述尿路微生物群可能会揭示新的诊断或治疗目标.
研究的目的:
- 为了比较OAB和没有OAB的个体中的细菌尿道微生物组合.
- 调查尿道微生物组组成如何随OAB表型,并发症,抗生素暴露和治疗反应而变化.
主要方法:
- 分析了OAB和没有OAB的女性的尿样.
- 使用16S rRNA测序确定了细菌概况.
- 代谢物概况是通过非目标代谢学生成的,并绘制了微生物-代谢物相互作用的地图.
主要成果:
- 在OAB和没有OAB的个体之间观察到尿道微生物组合的显著差异.
- 在患有OAB的个体中,诸如*Escherichia*,*Enterococcus*和*Proteus*等基因更为丰富.
- 在没有OAB的个体中, *Megasphaera* 和 *Scardovia* 较为丰富.
- 微生物组的组成也因OAB表型,糖尿病状况,抗生素病史和治疗反应而有所不同.
结论:
- 这项研究阐明了与OAB相关的独特的尿路微生物组概况.
- 研究结果强调了患者特征和治疗对尿道微生物群的影响.
- 这些结果支持开发微生物组调节策略,以补充目前的OAB治疗方法.
相关概念视频
Urinary Bladder
3.5K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.5K
Antibiotic Selection
60.2K
Overview
60.2K
Reflection of Waves
4.7K
When a wave travels from one medium to another, it gets reflected at the boundary of the second medium. A common example of this is when a person yells at a distance from a cliff and hears the echo of their voice. The sound waves (longitudinal waves) traveling in the air are reflected from the bounding cliff. Similarly, flipping one end of a string whose other end is tied to a wall causes a pulse (transverse wave) to travel through the string, which gets reflected upon reaching the wall. In...
4.7K
The Sense of Self: Reflected Self-Appraisal and Social Comparison
56.1K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
Introduction to Urinary System
9.3K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
9.3K
Disorders of the Urinary System
1.3K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
1.3K


