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食道状细胞癌的复发模式因瘤的位置和病理阶段而有所不同

Yura Ahn¹, Sang Min Lee¹, Jung Im Kim¹

¹Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Republic of Korea.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

|February 10, 2026

概括

食道平细胞癌 (ESCC) 的复发模式取决于瘤的位置和治疗. 肺部是远期复发最常见的地方,比二次肺癌更早出现.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
手术瘤学手术瘤学

背景情况:

oesophageal状细胞癌 (ESCC) 的复发模式是复杂的,受到多种因素的影响.
区分真正的复发与次级原发性恶性瘤对于准确的预后和治疗至关重要.

研究的目的:

研究主要瘤的位置,治疗方式和病理阶段如何影响ESCC复发模式.
要区分真正的瘤复发和次要原发性恶性瘤.

主要方法:

对953名接受治疗意图食道切除术的ESCC患者 (2010-2020年) 的回顾性分析.
患者按瘤位置 (上/中与下),病理阶段 (0-I与II-IV) 和治疗 (前置手术与新辅助化学辐射) 分类.
记录了复发模式 (局部区域,远程,混合) 和二次原发性恶性瘤;评估了复发后生存率 (PRS).

主要成果:

复发发生在23.4%的患者中,主要发生在手术后2年内.
前期手术的早期上/中ESCC显示出更高的局部区域复发率 (16.3%) 与下ESCC (6.7%),特别是在中枢/关节上节点.
远程复发在新辅助化疗组中更为常见 (19.6%对9.7%),肺部是最常见的部位.
二次性肺癌发生的时间明显晚于肺复发 (中位数为58.3个月与6.9个月).
混合复发与更糟糕的PRS (aHR=1.77) 有关.

结论:

ESCC复发模式受到主要瘤位置,治疗方式和病理阶段的显著影响.
肺是远程ESCC复发的主要部位,表现得比二次肺癌更早.
了解这些模式对于定制治疗和改善ESCC患者的治疗结果至关重要.

关键词:

新辅助疗法是一种新辅助疗法.消化管癌是一种食道癌症.消化腺切除术 (ESO) 是一种消化腺切除术.复发性复发性复发性监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督

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