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Updated: Feb 12, 2026

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Doppler Optical Coherence Tomography of Retinal Circulation
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糖尿病视网膜新血管化的非侵入性评估使用24×20毫米超广场光学连贯性断层扫描血管学
Kangyan Zheng1,2, Peiyao Lu2,3, Jiayi Huang2
1Shantou University Medical College, Shantou, China.
Retina (Philadelphia, Pa.)
|February 10, 2026
概括
超广场光学连贯断层扫描血管造影 (UWF-OCTA) 能够有效检测糖尿病视网膜新血管化,显示高精度和与光素血管造影的一致性. 将UWF-OCTA与彩色底部摄影相结合,为糖尿病视网膜病变评估提供了一个可靠的,非侵入性的替代方案.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 糖尿病视网膜病变研究研究
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因,其特征是新血管化 (NV).
- 准确检测NV对于及时治疗和预防视力损伤至关重要.
- 当前像超宽场光素血管造影 (UWF-FA) 这样的成像模式是有效的,但具有侵入性.
研究的目的:
- 评估单次捕获的24×20mm超广场光学连贯性断层扫描血管学 (UWF-OCTA) 的疗效,以检测糖尿病视网膜新血管化 (NV).
- 为了比较UWF-OCTA性能与超广场彩色底部摄影 (UWF-CFP) 和UWF-FA.
- 评估UWF-OCTA和UWF-FA之间的诊断协议,使用UWF-FA作为黄金标准.
主要方法:
- 一项涉及90只眼睛的横截面研究,来自56名参与者的DR.
- 这些图像是使用Optos California (UWF-CFP,UWF-FA) 和Toward Pi BM400K (UWF-OCTA) 系统获得的.
- 基于预定义的标准进行NV分级;使用SPSS v19进行统计分析,包括类内相关系数 (ICC),灵敏度和特异性.
主要成果:
- 对于NV检测,UWF-OCTA表现出高灵敏度 (0.97),特异性 (1.0) 和精度 (0.99).
- 在UWF-OCTA和UWF-FA之间达成的优秀协议是24×20毫米范围内的NV计数 (ICC=0.994) 和总NV计数 (ICC=0.904).
- UWF-OCTA和UWF-CFP的全景组合显著改善了NV检测 (ICC=0.988).
结论:
- 24×20毫米UWF-OCTA是检测糖尿病视网膜新血管化的高效工具.
- UWF-OCTA与UWF-FA达成了良好的协议,证明了其可靠性.
- UWF-OCTA和UWF-CFP的组合为DR评估提供了一个可靠的,非侵入性的UWF-FA替代方案.
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