神经认知结果及其与结核性脑膜炎中的基于大脑的生物标志物的相关性:一项前性研究
Sanchit Shailendra Chouksey1, Varun Kumar Singh1, Rameshwar Nath Chaurasia1
1Department of Neurology, Institute of Medical Science, Banaras Hindu University, Varanasi, India.
The American journal of tropical medicine and hygiene
|February 10, 2026
概括
结核性脑膜炎 (TBM) 通常会导致认知障碍,特别是注意力和记忆力. 虽然一些生物标志物与TBM严重程度相关,但它们与认知恢复的联系需要进一步研究.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经免疫学 神经免疫学
背景情况:
- 结核性脑膜炎 (TBM) 是一种严重的中枢神经系统感染,具有高死亡率和神经缺陷.
- 大脑脊髓液 (CSF) 生物标志物与TBM的炎症反应有关,但它们与认知结果的关联仍然不清楚.
研究的目的:
- 评估TBM早期阶段 (1级和2级) 患者的认知特征.
- 在TBM患者中研究认知功能和免疫学/基于大脑的CSF生物标志物之间的相关性.
主要方法:
- 在基线和3个月的随访期间,对60名确定的/可能的TBM (1-2级) 的成年患者进行了认知,神经成像和CSF生物标志物 (IFN-γ,IL-6,TNF-α,S100B,MMP-9,NSE) 的评估.
- 用印度医学研究理事会神经认知工具箱电池评估认知功能.
主要成果:
- 大多数TBM患者表现出基线认知障碍,特别是注意力,执行功能和记忆力.
- 3个月后观察到部分认知恢复,在1级TBM中更为明显.
- 与对照组相比,在TBM患者中发现炎症 (IL-6,IFN-γ,TNF-α) 和大脑生物标志物 (S100B,NSE) 的升高,但与认知结果的相关性较弱.
结论:
- 神经认知障碍在TBM中很普遍,影响各种领域.
- 生物标志物可能为监测TBM严重程度和恢复提供潜力,尽管与认知结果的相关性需要进一步调查.
- 需要进行更大规模的长期研究,以阐明这些生物标志物在TBM神经认知结果中的确切作用.
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