在体积调节性弧线治疗中以算法为基础确定廊角度范围,用于肝脏的立体体态体辐射疗法
Hideharu Miura1, Minoru Nakao1, Masanori Ochi2
1Hiroshima High-Precision Radiotherapy Cancer Center, 3-2-2 Futabanosato Higashi-ku, Hiroshima 732-0057, Japan; Department of Radiation Oncology, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan.
概括
开发了一种算法,通过最大限度地减少对正常肝脏组织的辐射来优化肝癌体积调节弧线疗法 (VMAT) 的门架角度. 这种方法与专家的规划相匹配,减少了变化,并简化了治疗.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 癌症治疗方法 癌症治疗方法
背景情况:
- 卷度调节弧线疗法 (VMAT) 是一种用于治疗肝癌的放射治疗技术.
- 在VMAT中优化门架角度选择对于最小化对风险器官的剂量至关重要,例如正常的肝脏组织.
- 目前用于门架角度选择的方法可能是主观的,并且在处理规划者之间有所不同.
研究的目的:
- 开发和评估一种基于算法的方法,用于确定VMAT中肝癌的最佳廊角度范围.
- 主要目标是尽量减少穿过正常肝脏组织的光束路径长度.
主要方法:
- 开发了一种算法,使用DICOM轮计算从肝脏表面到目标中心的最短光束路径.
- 为15名肝癌患者生成了三个VMAT计划:自动化 (基于算法),专家手册和初学者手册.
- 根据廊角度范围,肝脏路径长度,剂量-体积参数,监测单元以及对角度一致的Jaccard相似性进行了对比.
主要成果:
- 自动化计划实现了与专家计划相比的平均正常肝脏路径长度 (35.0毫米 vs 34.6毫米),并且比初学者计划 (39.3毫米) 短.
- 雅卡德相似系数显示自动化和专家计划之间的高度一致性 (0.86),与初学者计划 (0.80) 的良好一致性.
- 在所有计划类型中,剂量计参数和监测单元相似,没有显著差异.
结论:
- 算法方法提供了一种简单,定量和可重复的方法来确定肝脏VMAT中的门架角度.
- 这种方法有效地复制专家规划师的决策,减少规划师之间的变化,并可以标准化廊角度选择.
- 该算法有可能简化肝癌的VMAT治疗规划过程.
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