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对覆盖运动皮质的脑膜瘤进行玛刀放射手术的结果
Neil D Almeida1, Shefalika Prasad2, Venkatesh Madhugiri1
1Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA; Department of Radiation Oncology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
概括
玛刀放射性手术 (GKRS) 有效地控制运动皮质脑膜瘤,特别是小的,低度的瘤. 这种治疗为这个关键的大脑区域提供了一种安全的选择,并经过仔细的患者选择.
科学领域:
- 神经外科 神经外科
- 辐射瘤学 辐射瘤学
- 在瘤学瘤学.
背景情况:
- 运动皮层脑膜瘤由于潜在的神经损伤而存在治疗挑战.
- 玛刀放射性手术 (GKRS) 在治疗这些瘤的有效性方面得到了评估.
研究的目的:
- 评估用GKRS治疗的运动皮质脑膜瘤患者的临床,成像和生存结果.
- 确定影响瘤控制和无进展生存的因素.
主要方法:
- 来自机构注册表的临床,成像和生存数据的回顾性分析.
- 对治疗量和瘤反应评估进行系列MRI审查.
- 使用标准生存方法分析无进展生存率和瘤控制率.
主要成果:
- 47名患有58例运动皮层脑膜瘤的患者接受了GKRS (前期或辅助) 的治疗.
- 世卫组织第1级脑膜瘤和较小的治疗量 (<5厘米) 显示无进展的生存时间明显更长.
- 脑膜瘤等级和治疗量与瘤控制有显著的关联.
结论:
- GKRS证明了对运动皮层脑膜瘤的有效瘤控制.
- 这种治疗对于小体积的WHO级1病变特别有益.
- 对于这个雄辩的地点,GKRS是一种安全有效的选择,需要仔细的患者选择和剂量规划.
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