补充剂和男性生育能力:机制性见解和治疗潜力
Neeraj Patel1, Riya Mishra2, Muhammad Afzal3
1School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India.
概括
(Se) 对男性生殖健康至关重要,增强精子质量和生育能力. 最佳摄入量至关重要,因为缺乏和过量都会损害男性的生育能力.
科学领域:
- 生殖生物学 生殖生物学
- 营养生物化学 营养生物化学
- 环境健康 环境健康
背景情况:
- (Se) 是一种重要的微量矿物质,在男性生殖健康中起着关键作用.
- 它的生物化学形式,抗氧化功能以及与其他微量营养素的相互作用显著影响生育结果.
- 以前的审查没有全面综合这些方面,需要进行更新的审查.
研究的目的:
- 提供关于在男性生殖健康中的作用的全面审查.
- 为了合成关于的生物化学形式,抗氧化功能以及对精子参数和生育能力的影响的信息.
- 在临床环境中概述可行的补充和监测策略.
主要方法:
- 使用PubMed,Scopus和Web of Science (2000-2025) 进行了一次系统的文献审查.
- 研究重点关注代谢,蛋白活性 (GPx1/4,SELENOP),剂量反应关系以及与维生素E和的相互作用.
- 收集和合成了关于形式,抗氧化酶调节,氧化应激标志物,精子功能,激素合成和毒性的数据.
主要成果:
- 有机形式表现出优越的生物可用性和抗氧化活性,减少胚胎细胞脂质过氧化.
- 最佳的食度 (例如,0.25-1.0毫克/公斤) 最大化精子生成;元素纳米显示出有前途.
- 人类研究表明,每天100微克可以改善精子的运动性和父性,而过量摄入 (>300微克/天) 则会损害功能. 与维生素E或一起补充可以增强抗氧化剂防御.
结论:
- 对男性生殖健康至关重要,具有剂量依赖的抗氧化和内分泌作用.
- 最佳的形式,剂量和与其他微量营养素的组合需要进一步的临床研究.
- 平衡摄入量对于最大限度地提高生育效益和避免潜在的U形毒性至关重要.
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