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Updated: Feb 12, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
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通过 Src 介导的 PHB2 酸化通过肝细胞癌中的心素分离破坏了线粒体晶状体

Zhehua Shao1, Xinnuo Yang2, Binben Wang3

  • 1Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Redox biology
|February 10, 2026
PubMed
概括

Src 激酶通过酸化禁忌素2 (PHB2) 触发肝细胞癌 (HCC) 的生长,破坏线粒体结构并促进代谢转变. 针对这种酸化可能会提供新的HCC治疗策略.

关键词:
卡迪奥利平因 (cardiolipin) 是一种心脏蛋白质.肝细胞癌 (HCC) 是一种肝细胞癌.线粒体晶体中的线粒体晶体.禁止使用这种药物.氧化还原平衡 (redox homeostasis) 是一种方法.通过 Src 介导的酸化.

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