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Updated: Feb 12, 2026

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
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Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

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发现和优化针对急性髓性白血病的Menin-MLL抑制剂

Qitao Xiao1, Yuxian Wang2, Zheyuan Shen1

  • 1Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Zijingang Campus, Hangzhou, 310058, China.

European journal of medicinal chemistry
|February 10, 2026
PubMed
概括

一个机器学习策略确定了thio[2,3-d]pyrimidine衍生物作为 menin 抑制剂. 化合物A13显示强烈的抗白血病活性和有利的药理动力学,表明其对MLL重组的AML治疗的潜力.

关键词:
在MLL-R AML中,我们可以看到 AML.机器学习是机器学习.这是一种男性抑制剂.乙烯基[2,3-d] 胺氨酸

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