关于微波切除肺瘤中的热力学合损伤机制的数值模拟研究
1College of Chemistry and Life Science, Beijing University of Technology, Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Beijing, 100124, China.
Journal of thermal biology
|February 10, 2026
概括
肺癌微波切除 (MWA) 创建了两个损伤区域. 了解冷却过程中的热应力演变和机械变化是防止腔等并发症和提高MWA安全性的关键.
科学领域:
- 生物医学工程 生物医学工程
- 计算力学 计算力学 计算力学
- 在瘤学瘤学.
背景情况:
- 肺癌需要有效的治疗方法,如微波切除 (MWA).
- 在MWA期间的热应激和肺孔结构中的术后并发症 (例如空洞) 之间的相关性尚未完全理解.
- 需要准确的建模来预测和减轻MWA诱导的组织损伤.
研究的目的:
- 阐明肺MWA期间热力学合损伤机制.
- 识别不同的风险区域及其机械特性.
- 为更安全的MWA策略提供理论基础.
主要方法:
- 构建一个电磁热力学多物理结合的有限元模型.
- 使用多孔介质理论和双相滞后传热模型对肺MWA进行模拟.
- 分析热应力演变,相位变化和在剥离和冷却过程中的机械反应.
主要成果:
- 确定两个损坏风险区域:一个具有高等效应力的高温核心区域和一个具有剪切应力度和潜在撕裂损伤的过渡区域.
- 在冷却阶段观察显著的应力再分配和放松.
- 确认不可逆转的相变损伤驱动了废弃区的永久体积减少.
结论:
- 肺部MWA涉及热力机械合损伤的"双重风险区"机制.
- 在冷却阶段的机械演变对于理解MWA结果至关重要.
- 建立机械值可以指导开发精确和安全的肺MWA策略.
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