肠 - 盘轴:解开微生物组在腰椎间盘的作用
Luca Ambrosio1,2, Jordy Schol3,4, Stone Sima5
1Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Neurospine
|February 10, 2026
概括
肠道微生物组可能通过影响炎症和疼痛来影响腰椎间盘 (LDH). 虽然是初步的,但研究表明肠道失调和磁盘细菌起作用,需要进一步研究微生物向治疗腰部疼痛的方法.
科学领域:
- 微生物学 微生物学
- 整形外科 整形外科 整形外科
- 免疫学 免疫学 免疫学
背景情况:
- 腰椎间盘 (LDH) 是腰部疼痛的常见原因,传统上涉及机械和退行性因素.
- 持续的症状表明,除了机械原因之外,还存在潜在的生物机制.
- 肠-脊柱轴概念强调了微生物组在炎症,免疫反应和疼痛敏感性方面的潜在作用.
研究的目的:
- 审查当前关于肠道和局部磁盘微生物群在腰椎间盘 (LDH) 中的作用的证据.
- 探索潜在的系统和局部机制,将微生物组与LDH病理生理学联系起来.
主要方法:
- 在PubMed/MEDLINE和Scopus的系统文献搜索到2025年6月.
- 遵守PRISMA-ScR (系统性审查的首选报告项目和范围审查的元分析扩展) 准则.
- 包括26项临床前和临床研究.
主要成果:
- 动物模型表明,LDH可以改变肠道微生物群,微生物群干预可以减少炎症和疼痛.
- 人类研究不一致地检测到像Cutibacterium acnes这样的细菌在椎间板的椎间板中,有潜在的污染问题.
- 研究人员指出,细菌殖民和莫迪克变化,盘子高度下降和慢性疼痛之间存在关联.
- 肠道功能失调和微生物代谢物可能会影响涉及磁盘退化和疼痛感知的全身途径.
结论:
- 通过系统和局部机制,证据表明微生物组参与LDH病理生理学的生物学可信性.
- 目前的数据是初步的,缺乏观察到的相关性的机械确认.
- 需要进一步的标准化,污染意识的研究来确定因果关系,并探索基于微生物组的LDH治疗方法.
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