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Updated: Feb 12, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
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TAFA4通过调节巨细胞极化和抑制ROS-NLRP3炎症酶激活来缓解椎间盘退化

Jiaheng Han1,2, Jie Huang3, Zhili Ding2,4

  • 1Department of Orthopaedics, School of Medicine, South China University of Technology, Guangzhou, China.

Neurospine
|February 10, 2026
PubMed
概括

通过调节巨细胞活动和减少氧化应激,来自神经元的TAFA4 (TAFA 基因基因类似于家族成员4) 延缓椎间盘退化. 这种神经免疫通路为磁盘疾病提供了潜在的治疗点.

关键词:
在GINIP+神经元中.椎间盘退化 椎间盘退化巨细胞的两极分化在NLRP3炎症酶体中,NLRP3炎症有反应性氧物种的反应性氧物种.在TAFA4中,TAFA4就是TAFA.

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