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发现了来自Lactobacillaceae的生物活性甘油片段,在宿主中提供肠道保护

Yaquan Liang¹, Christopher Adamson¹, Chenyu Li¹

¹School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.

Cell chemical biology

|February 10, 2026

概括

肠道细菌释放的甘油片段 (PGNs) 调节宿主免疫力. 研究人员确定了乳酸菌家族作为二糖PGN的关键生产者,这表明对肠道炎症具有治疗潜力.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

由肠道细菌衍生而来的酸糖片段 (PGN) 是重要的信号分子.
从特定的肠道细菌中产生可溶性PGN的产生和功能仍未得到充分研究.

研究的目的:

研究个体肠道细菌物种分泌的可溶性PGN的生产和功能作用.
探索分糖PGN在调节宿主免疫反应和肠道炎症方面的治疗潜力.

主要方法:

针对性的液体染色学-并联质谱学 (LC-MS/MS) 用于对PGN进行分析.
进行了分糖体PGN的化学合成.
用小鼠巨细胞来评估免疫激活和耐受性.
使用德克斯硫酸 (DSS) 诱导的大肠炎小鼠模型来评估治疗疗效.

主要成果:

乳酸菌被确定为培养超水生物中二糖PGN的主要生产者.
合成的分糖体PGN激活了哺乳动物的NOD2传感器.
用分糖基PGN启动巨细胞诱导了对TLR2/4联结体刺激的耐受性.
在大肠炎小鼠模型中,服用分糖体PGN GM-AQK可缓解肠道炎症.

结论:

来自乳杆菌家族的二糖化PGN是生物活性分子,通过NOD2与宿主免疫系统相互作用.
持续接触生物活性PGN可以塑造宿主免疫反应,可能诱导免疫耐受性.
天然分糖体PGN代表了治疗性干预肠道炎症的有希望的后生物候选人.

关键词:

这是LC-MS/MS.来自乳酸菌家族的酸甘油碎片.在NOD2信号传输中.免疫耐受性免疫耐受性肠道保护肠道保护

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