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Updated: Feb 12, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
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由YARS2和线粒体COX1突变之间的协同作用引起的视觉神经病变

Huiying Li1, Cheng Ai1, Xiaofen Jin2

  • 1Center for Mitochondrial Biomedicine and Department of Ophthalmology, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China; Center for Genetic Medicine, International School of Medicine and International Institute of Medicine, Zhejiang University, Yiwu, Zhejiang 322000, China; Institute of Genetics, Zhejiang University, Hangzhou, Zhejiang, 310058, China.

Journal of genetics and genomics = Yi chuan xue bao
|February 10, 2026
PubMed
概括

勒伯遗传性视神经病 (LHON) 研究揭示了核和线粒体DNA突变如何相互作用导致视力丧失. 针对Yars2的基因治疗显示出通过恢复线粒体功能和视力来治疗LHON的前景.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.铁化是铁化的一种.基因治疗是一种基因疗法.线粒体DNA突变的突变线粒体中的铁基-tRNA合成酶.视觉神经病变是一种视觉神经病变.氧化酸化是一种氧化酸化.

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