电喷涂的酸盐涂层酸盐微球用于酸/乌罗利丁的输送:特征,消化和抗氧化
Jing Yang1, Xiaoqian Zheng1, Xingyu Zhou2
1School of Chemistry and Chemical Engineering, North University of China, Taiyuan, Shanxi, 030051, China; Dezhou Industrial Technology Research Institute of North University of China, Dezhou, Shandong, 533034, China.
International journal of biological macromolecules
|February 10, 2026
概括
基涂层的甲基酸盐微球有效地封装了酸和乌罗,提高了它们在消化过程中的稳定性. 这种新型的多糖载体系统提高了生物可用性,并解决了这些重要的生物活性物质的代谢变异性.
科学领域:
- 材料科学:开发基于多糖的新型药物输送系统.
- 生物化学:生物活性化合物的封装和稳定.
- 药理学:改善生物可用性和减少代谢变异性的策略.
背景情况:
- 基酸 (EA) 的低生物可用性和urolithins的代谢变异性限制了它们的治疗潜力.
- 天然多糖类,如藻酸盐 (SA) 和酸盐 (CS),为药物输送提供生物相容的平台.
- 电子喷涂是一种多功能技术,用于制造具有可控形态的微/纳米粒子.
研究的目的:
- 用于制造酸盐涂层的酸微球,用于封装酸和乌罗.
- 评估开发的微球的物理化学特性,药物负载和稳定性.
- 评估这些微球在改善封装生物活性物质的生物可用性和管理代谢变异性的潜力.
主要方法:
- 使用电喷涂制造核心外结构的CS涂层SA微球.
- 埃拉基酸 (EA) 和尿素素 (Uro A,Uro B,Uro C,Iso A) 的封装.
- 使用FTIR,TGA/DTG进行表征,并评估封装效率和抗氧化活性.
- 在体外消化稳定性的评估.
主要成果:
- 统一的微球尺寸 (<100微米) 通过1%的SA实现,在含药物配方中具有60-88%的封装效率.
- FTIR分析证实了成功的药物嵌入和药物与多糖之间的非共价相互作用.
- 装有药物的微球表现出增强的热稳定性,药物聚合物相互作用提高了耐热性.
- 在体外消化过程中减轻了32-69%的药物损失,同时保持了结构完整性.
结论:
- 覆盖CS的SA微球是一种有效的多糖体载体,可以在消化过程中保护生物活性物质.
- 该系统提供了一种有希望的策略,以克服EA的低生物可用性和urolithins的代谢变异性.
- 开发的微球显示出增强天然抗氧化剂的潜在作用.
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