葡萄酒消费,地中海饮食和两个西班牙队列中的心血管风险
Miguel A Martínez-González1,2,3,4, Maira Bes-Rastrollo1,2,3, Carmen Sayon-Orea1,2,3
1Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain.
European heart journal
|February 10, 2026
概括
地中海饮食 (MedDiet) 是有益的,但葡萄酒.
科学领域:
- 心血管疾病的研究研究.
- 营养流行病学 营养流行病学
- 饮食模式和健康结果
背景情况:
- 地中海饮食 (MedDiet) 与许多健康益处有关.
- 葡萄酒消费在MedDiet中的作用仍然是争论的主题.
- 心血管疾病 (CVD) 和全因死亡率是严重的健康问题.
研究的目的:
- 为了调查遵守MedDiet,与或没有葡萄酒消费,和主要的心血管疾病事件之间的关联.
- 评估MedDiet (含葡萄酒或不含葡萄酒) 坚持和所有原因死亡率之间的关系.
- 评估葡萄酒作为MedDiet的一个组成部分对健康结果的影响.
主要方法:
- 从PREDIMED试验 (7447名参与者) 和SUN队列 (23,133名参与者) 的数据分析.
- 使用经过验证的14项调查问卷评估MedDiet的坚持,其中包括一个葡萄酒消费项目 (切断值:每周7杯).
- 心血管疾病事件被追踪了4.8年;所有原因的死亡率被追踪了17年 (PREDIMED) 和22年 (SUN).
主要成果:
- 在PREDIMED研究中,与不合格者相比,遵守包括葡萄酒在内的MedDiet与较低的心血管疾病风险 (HR 0.55) 和全因死亡率 (HR 0.67) 有关.
- 不含葡萄酒的MedDiet坚持表明对心血管疾病 (HR 0.84) 和死亡率 (HR 0.77) 的影响较小.
- 两组队伍的综合分析表明,在MedDiet中的葡萄酒消费与所有原因死亡率的降低有关 (P = .01).
结论:
- 在PREDIMED试验中,作为MedDiet的一部分的适度葡萄酒消费可能与降低死亡率和心血管疾病风险有关.
- 调查结果表明,在MedDiet的背景下,葡萄酒可能有好处,尽管没有得到明确的证据.
- 由于不显著的相互作用和潜在的偏差,建议谨慎进行进一步调查.
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