通过水热部分相转换制造双相氧酸盐/硫酸块,用于骨替代品
Sunarso Sunarso1, Gita Andani Pradana2, Syifaa Sagakirana2
1Department of Dental Materials Science, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
European journal of dentistry
|February 10, 2026
概括
这项研究通过水热处理将石膏块转化为双相酸/硫酸 (HA/CS) 块. 由此产生的HA / CS块显示可溶性降低和可接受的细胞毒性,用于潜在的生物医学应用.
科学领域:
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
- 生物矿物化 生物矿物化
背景情况:
- 酸/硫酸 (HA/CS) 复合物是有前途的生物材料.
- 开发高效的HA/CS制造方法对于其应用至关重要.
- 石膏 (硫酸二水合物) 是一种丰富且具有成本效益的前体材料.
研究的目的:
- 使用部分热水转换从石膏制造双相HA/CS块.
- 描述合成的HA/CS块的相组合,机械强度,可溶性和细胞毒性.
主要方法:
- 石膏块在150°C的Na3PO4溶液中经过热水处理,持续时间不同 (6,12,24小时).
- 用X射线衍射分析了相位组成.
- 评估了直径拉伸强度 (DTS),Tris-HCl缓冲液中的溶解度,以及细胞培养中的体外细胞毒性.
主要成果:
- 热水处理成功地产生了双相HA/CS,随着时间的推移增加了酸含量.
- 与纯石膏 (2.06 MPa) 相比,HA/CS块的DTS显著减少 (0.5-0.7 MPa).
- 与石膏 (206.15 mg/L) 相比,HA/CS块的可溶性降低了 (24-HA/CS的最低值为94.70 mg/L),细胞毒性测试显示细胞活力超过70%,符合ISO标准.
结论:
- 石膏的部分热水转化是一种有效的方法来生产双相HA/CS块.
- 该过程允许可调节的相组合,从而降低溶解度和可接受的细胞毒性.
- 这些HA/CS块显示出在骨再生和其他生物医学应用中使用的潜力.
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