光生物调节激活的TGF-β1在调节巨细胞对Bothrops jararacussu毒液的反应中具有分立的作用
Amanda Cabral David1,2, Mahmud Amin2, Ridham Varsani2
1Programa de Pós Graduação em Medicina, Universidade Nove de Julho, São Paulo, Brazil.
Journal of biophotonics
|February 10, 2026
概括
光生物调节 (PBM) 疗法可以减轻Bothrops jararacussu蛇毒 (BjsuV) 对巨细胞的有害影响. PBM可以抵消毒素引起的炎症和细胞损伤,提供潜在的治疗益处.
科学领域:
- 生物医学科学 生物医学科学
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 蛇毒 Bothrops jararacussu蛇毒 (BjsuV) 造成严重的组织损伤,目前的抗毒疗法不足以治疗肌肉损伤.
- 光生物调制 (PBM) 是一种新兴的抗炎疗法,具有作为辅助治疗的潜力.
研究的目的:
- 研究PBM对巨细胞功能的影响,特别是它们对BjsuV的反应和TGF-β1.1.的作用.
- 评估PBM在抵消BjsuV诱导的细胞损伤和炎症方面的潜力.
主要方法:
- 巨细胞暴露于BjsuV,TGF-β1,一个TGF-β抑制剂 (SB431542),和PBM (660nm红色或810nm近红外激光).
- 在各种治疗组合后,评估了巨细胞的存活率,迁移和细胞化.
主要成果:
- 暴露于BjsuV减少了巨细胞的存活率和迁移,但增加了细胞化.
- PBM治疗显著抵消了BjsuV对巨细胞生存和迁移的负面影响.
- 作为对BjsuV.BjsuV.BjsuV.的反应,PBM调节的巨细胞细胞形成.
结论:
- PBM对巨细胞表现出抗炎作用,这表明它对毒素引起的伤害具有治疗潜力.
- 了解PBM在调节巨细胞信号通路中的机制,可以增强未来的临床应用.
更多相关视频
06:54Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
14.5K
08:52Neuron-Macrophage Co-cultures to Activate Macrophages Secreting Molecular Factors with Neurite Outgrowth Activity
Published on: March 30, 2018
9.4K
相关概念视频
Discrete Fourier Transform
922
The Discrete Fourier Transform (DFT) is a fundamental tool in signal processing, extending the discrete-time Fourier transform by evaluating discrete signals at uniformly spaced frequency intervals. This transformation converts a finite sequence of time-domain samples into frequency components, each representing complex sinusoids ordered by frequency. The DFT translates these sequences into the frequency domain, effectively indicating the magnitude and phase of each frequency component present...
922
TGF - β Signaling Pathway
10.6K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.6K
Discrete-time Fourier transform
1.1K
The Discrete-Time Fourier Transform (DTFT) is an essential mathematical tool for analyzing discrete-time signals, converting them from the time domain to the frequency domain. This transformation allows for examining the frequency components of discrete signals, providing insights into their spectral characteristics. In the DTFT, the continuous integral used in the continuous-time Fourier transform is replaced by a summation to accommodate the discrete nature of the signal.
One of the notable...
One of the notable...
1.1K
Basic Discrete Time Signals
741
The unit step sequence is defined as 1 for zero and positive values of the integer n. This sequence can be graphically displayed using a set of eight sample points, showing a step function starting from n=0 and remaining constant thereafter.
The unit impulse or sample sequence is mathematically expressed as zero for all n values except at n=0, where it is one. The unit impulse sequence, denoted by δ(n), is the first difference of the unit step sequence, while the unit step sequence u(n) is the...
The unit impulse or sample sequence is mathematically expressed as zero for all n values except at n=0, where it is one. The unit impulse sequence, denoted by δ(n), is the first difference of the unit step sequence, while the unit step sequence u(n) is the...
741
Discrete-Time Fourier Series
719
The Discrete-Time Fourier Series (DTFS) is a fundamental concept in signal processing, serving as the discrete-time counterpart to the continuous-time Fourier series. It allows for the representation and analysis of discrete-time periodic signals in terms of their frequency components. Unlike its continuous counterpart, which utilizes integrals, the calculation of DTFS expansion coefficients involves summations due to the discrete nature of the signal.
For a discrete-time periodic signal x[n]...
For a discrete-time periodic signal x[n]...
719
Humoral Immune Responses
84.1K
Overview
84.1K
