在献血者中虚假阳性感染查结果
Sofie Dolores Holm Müller1, Mie Topholm Bruun1,2, Jørgen Georgsen1,2
1Clinical Immunology Research Unit, Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
Vox sanguinis
|February 10, 2026
概括
新献血者,假阳性检测结果 (FPTR) 有显著更高的风险经历第二个FPTR. 这一发现表明,在最初的FPTR之后推迟新捐赠者的潜在好处是为了降低成本和减少捐赠者的担忧.
科学领域:
- 输血医学 输血医学
- 临床实验室科学 临床实验室科学
- 免疫学 免疫学 免疫学
背景情况:
- 用于献血查的高灵敏度测试可以产生假阳性测试结果 (FPTR).
- 造成FPTR的原因是多因素的,包括依赖和不依赖的因素.
- FPTR会带来行政费用,需要确认性测试,并可能引起延期捐赠者的焦虑.
研究的目的:
- 调查与血液供献者重复假阳性测试结果 (FPTRs) 相关的风险因素.
- 确定捐赠者的特征是否影响第二次FPTR的可能性.
主要方法:
- 从2021年1月到2023年11月的献血者查数据的回顾性分析.
- 使用Abbott Alinity i和罗氏科巴斯MPX试验识别第一次和第二次FPTR.
- 后勤回归分析,以评估捐赠者身份 (新者与重复者),性别,年龄和捐赠之间的间隔对第二次FPTR风险的影响.
主要成果:
- 在来自38,962名捐赠者的223,323份捐赠中,记录了216份FPTR.
- 在83名第一次FPTR的捐赠者中,有67.5%的捐赠者进行了第二次FPTR.
- 具有初始FPTR的新供体具有显著更高的第二次FPTR风险 (aOR=6.06),发生在89.5%的此类病例中.
结论:
- 经历了初次FPTR的新献血者表现出后续FPTR的风险大幅增加.
- 从道德和经济的角度来看,推迟新捐赠者在第一次FPTR之后可能是明智的.
- 一些捐赠者的持续FPTR,甚至在长时间内,表明有很多独立因素的影响.
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