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内毒素标志物在患有肥胖的青少年中升高,有或没有与代谢功能障碍相关的脂肪性肝病

Alison M Boone¹, Alyssa M Bartlett¹, Jordan A Bays¹

¹Department of Pediatrics, Section of Diabetes & Endocrinology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.

Pediatric obesity

|February 10, 2026

概括

在肥胖的青少年中,内毒素活性和炎症标志物升高,但在轻度至中度代谢功能障碍相关的脂肪性肝病 (MASLD) 患者中没有显著增加. 这表明肥胖,而不是MASLD本身,推动了青少年的这些变化.

科学领域:

儿科胃肠病学儿科胃肠病学
肝病学肝病学是一种肝病学.
代谢障碍代谢障碍代谢障碍

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是儿童群体日益关注的问题.
以前在成人和动物模型上的研究表明,肠道内毒素和MASLD发展之间存在联系.
关于内毒素在青少年MASLD中的作用的证据仍然有限且不一致.

研究的目的:

在被诊断为MASLD的青少年中调查内毒素活性水平.
为了确定特定的内毒素标志物是否与青少年的肝病严重程度相关.
评估内毒素标志物和儿科MASLD中的组织学发现之间的关联.

主要方法:

血清样本被分析为内毒素核心抗体 (EndoCab IgG),脂多糖结合蛋白 (LBP),可溶性CD14 (sCD14) 和C反应蛋白 (CRP).
参与者包括了活检证明的MASLD和肥胖的青少年,肥胖但没有MASLD的对照组和正常体重的对照组.
统计分析比较了不同组的标志物水平,并将它们与身体组成和肝脏组织学相关联.

主要成果:

与正常体重对照人群相比,患有MASLD和肥胖 (没有MASLD) 的青少年显示EndoCabIgG,LBP和CRP水平增加.
腰筋压和腰筋压水平与总体脂肪和干脂肪百分比呈正相关性.
在MASLD组内,没有根据性别或肝病严重程度 (肥胖度,纤维化阶段) 观察到内毒素标志物的显著差异.

结论:

青少年的肥胖与内毒素活性和炎症标志物的增加有关.
这些标志物在患有轻度至中度MASLD的青少年中没有进一步升高,与仅患有肥胖症的青少年相比.
这些发现表明,一般的肥胖,而不是具体的MASLD,可能会推动这个年龄组观察到的内毒素标志物的增加.

关键词:

马什 (MASH) 是一个非常重要的产品.马斯尔德马斯尔德是什么意思纤维化纤维化肠道透性的肠道透性这是一种炎症炎症炎症炎症.儿科儿科儿科蒸汽症是一种蒸汽症.

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