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Updated: Feb 12, 2026

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Published on: June 28, 2018

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由Ptbp2稳定的DNA聚合酶kappa与MRE11相互作用,并促进白血病中的基因组不稳定性

Shristi Lama1,2, Bibhudev Barik1,2, Sajitha Is3

  • 1Cancer Biology Group, Institute of Life Sciences, Nalco Square, Bhubaneswar, India.

Cell death discovery
|February 10, 2026
PubMed
概括

聚皮里米丁管结合蛋白2 (Ptbp2) 稳定了DNA聚合酶卡帕 (Polk) mRNA,增加了其表达. 这种Ptbp2-Polk相互作用促进了基因组不稳定性和癌细胞存活率,特别是在慢性髓性白血病中.

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