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Updated: Feb 12, 2026

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
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An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

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在唐氏综合征基础前脑神经元中,BDNF-TrkB的贩运和信号受损

Emily Blackburn1,2,3, Nicol Birsa1, André Teixeira Lopes1

  • 1Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.

Cell death & disease
|February 10, 2026
PubMed
概括

唐氏综合症 (DS) 和阿尔茨海默氏症 (AD) 分享神经元缺陷. 这项研究揭示了DS基底前脑神经元中的Rab5过活化和内体功能障碍,损害了对神经元健康至关重要的神经营养信号传递.

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