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Updated: Feb 12, 2026

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通过NAPRT介导的去胺化NAD生物合成增强了结肠组织的弹性,并抑制了瘤发生

Xiaoyue Wu1, Jason G Williams2, Haoyang Liang3

  • 1Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.

Nature communications
|February 10, 2026
PubMed
概括

尼古丁酸基转移酶 (NAPRT) 的生理水平通过维持肠道上皮细胞的NAD水平来抑制瘤的形成. 缺乏NAPRT会损害DNA修复,增加对癌症和结肠炎的易感性.

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