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Updated: Feb 12, 2026

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准NHEJ通过MYC降解激活STING信号,以提高SCLC中的抗瘤免疫力

Subhamoy Chakraborty1, Andrew Elliott2, Utsav Sen3

  • 1Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.

Nature communications
|February 10, 2026
PubMed
概括

小细胞肺癌 (SCLC) 显示高PRKDC (DNAPKcs) 表达,阻碍免疫治疗. 抑制DNAPKcs激活了免疫反应,提高了SCLC免疫疗法的疗效.

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