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Updated: Jun 15, 2026

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
12:47

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

2'-O-甲基瓜诺辛RNA片段对抗TLR7和TLR8,以限制自身免疫力

Arwaf S Alharbi1,2,3, Sunil Sapkota4,5, Zhikuan Zhang6

  • 1Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

Nature immunology
|February 10, 2026
PubMed
概括

含有2'O甲基guanosine的宿主RNA片段作为Toll-like受体7 (TLR7) 和TLR8的对手,防止免疫激活. 这种对抗性位点的突变可以导致自身免疫性疾病.

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