围产期的微塑料暴露:对新生儿免疫和代谢编程的影响 - - 范围审查
Aditya Hemendra Bhatt1, Somashekhar Marutirao Nimbalkar2, Dipen Vasudev Patel1
1Department of Neonatology, Pramukhswami Medical College, Bhaikaka University, Karamsad, Gujarat, India.
概括
在产前期暴露于微塑料和纳米塑料会破坏新生儿的免疫和代谢编程. 早期暴露对终身健康问题构成风险,需要进行公共卫生干预.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 发展生物学 发展生物学
背景情况:
- 微塑料和纳米塑料 (MNP) 的污染是无处不在的,引发了人们对生命早期暴露的担忧.
- 了解MNP对新生儿发育的影响对于公共卫生至关重要.
- 关于MNP对新生儿免疫和代谢系统的影响的知识存在差距.
研究的目的:
- 综合研究MNP在产周期间的暴露.
- 评估MNP对新生儿免疫和代谢编程的影响.
- 为了确定新生儿的暴露途径和生物效应.
主要方法:
- 对实验性动物研究,人类临床数据和体外模型的范围审查.
- 对MNP生物分布,分子效应和长期后果的分析.
- 评估尺寸和剂量依赖的效应和暴露途径.
主要成果:
- MNPs穿过胎盘和哺乳障碍,在胎儿和新生儿组织中积累.
- 免疫系统的破坏包括炎症,氧化应激和肠道失调.
- 代谢障碍包括脂质失调,肝炎和肥胖风险.
- 动物模型显示神经发育和生殖毒性,具有跨代的影响.
结论:
- 早期MNP暴露严重影响新生儿免疫和代谢编程.
- 潜在的终身健康后果需要进一步的研究和干预.
- 方法的多样性和有限的人类数据需要标准化的评估和多学科的方法.
相关概念视频
The Scope of Physics
53.5K
Physics is concerned with the interactions of energy, matter, space, and time, in order to discover the underlying mechanisms that underpin all phenomena. The word "physics" comes from the Greek word "phúsis", which means nature. Physics seeks to comprehend the natural world around us at its most fundamental level. It emphasizes the use of quantitative laws to do this, which could be valuable in other fields that want to push the performance boundaries of present...
53.5K
The Periodic Table
118.4K
As early chemists discovered more elements, they realized that various elements could be grouped by their similar chemical behaviors. One such grouping includes lithium (Li), sodium (Na), and potassium (K). All of these elements are shiny, conduct heat and electricity well, and have similar chemical properties. A second grouping includes calcium (Ca), strontium (Sr), and barium (Ba), which also are shiny, good conductors of heat and electricity, and have chemical properties in common. However,...
118.4K
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.6K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Periodic Classification of the Elements
59.6K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
59.6K
What is Metabolism?
132.4K
Overview
132.4K


