1-45岁患者急性淋巴细胞白血病后的严重无毒性生存期:丹麦队列研究
Camilla Grud Nielsen1,2, Bodil Als-Nielsen1, Birgitte Klug Albertsen3
1Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Leukemia
|February 10, 2026
概括
在急性淋巴细胞白血病 (ALL) 幸存者中,长期严重的毒性很常见,影响生活质量. 严重无毒性生存率 (STFS) 比传统措施更好地捕捉到这些结果.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床试验 临床试验
背景情况:
- 急性淋巴细胞白血病 (ALL) 存活率的提高需要评估长期毒性.
- 传统的生存指标可能无法完全捕捉ALL幸存者的严重,症状性器官毒性的负担.
- 严重无毒性生存率 (STFS) 是评估严重毒性的新型共识指标.
研究的目的:
- 将新的严重无毒性生存率 (STFS) 测量方法应用于真实世界的数据.
- 在全国ALL队列中评估21种预定义的严重毒性病例的发生率.
- 为了比较儿科和成人ALL幸存者之间的STFS.
主要方法:
- 分析了一组全国范围的506名ALL患者 (年龄为1-45岁),接受NOPHO ALL2008协议治疗.
- 评估了21种预定义的严重毒性的发生率.
- 计算了无事件生存率和无严重毒性事件生存率,并在各年龄组之间进行了比较.
主要成果:
- 在五年内,无事件生存率为84.4%,严重毒性无事件生存率为78.4%.
- 成年人 (18-45岁) 的STFS (61.6%) 与儿童 (82.4%) 相比显著较低.
- 严重的骨髓缩和残疾性麻/神经病症是最常见的严重毒性. 青少年 (10-17岁) 呈现严重毒性的高风险,类似于成年人.
结论:
- 在所有幸存者中,严重的长期毒性是相当大的,通常被传统的结局措施所忽视.
- STFS测量提供了对ALL治疗结果的更全面的评估.
- 应将STFS纳入未来的临床试验,以改善结果评估和国际可比性.
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