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Updated: Feb 12, 2026

Recombineering Homologous Recombination Constructs in Drosophila
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Recombineering Homologous Recombination Constructs in Drosophila

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使用基于计算机断层扫描的基础模型预测同源复合缺陷和治疗反应:一项临床前研究

Sheng Kuang1, Lesley Schuitmaker2, Min Wu3

  • 1Department of Precision Medicine, GROW - Research Institute for Oncology and Reproduction, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands. sheng.kuang@maastrichtuniversity.nl.

NPJ precision oncology
|February 10, 2026
PubMed
概括

基础模型准确地分类同源复合缺陷 (HRD),并使用临床前小鼠CT扫描预测治疗反应,克服了动物研究中的数据限制.

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Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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