来自Thymus vulgaris的Box-Behnken优化的氧化铜纳米颗粒增强了对抗多药耐药细菌病原体的有效性,并表现出抗癌活性
Samah H Abu-Hussien1, Akebe Luther King2,3, Muhammad A Khan4
1Department of Agricultural Microbiology, Faculty of Agriculture, Ain Shams University, Cairo, 11241, Egypt. samah_hashem1@agr.asu.edu.eg.
Bioresources and bioprocessing
|February 10, 2026
概括
从Thymus vulgaris中绿色合成的氧化铜纳米颗粒显示出强大的抗微生物和抗癌作用. 这些来自植物的纳米颗粒与仁素具有协同作用,为对抗耐药性感染和癌症提供了一个有前途的平台.
科学领域:
- 纳米医学和药物发现
- 植物化学和自然产品
- 抗微生物和抗癌疗法 抗微生物和抗癌疗法
背景情况:
- 抗微生物药物耐药性和癌症正成为迫在眉的全球卫生挑战,需要新的治疗策略.
- 传统的治疗方法面临局限性,需要像植物介导纳米颗粒这样的创新平台.
- 粗腺体中含有丰富的植物化学物质,具有潜在的治疗应用.
研究的目的:
- 使用 Thymus vulgaris 提取物进行绿色合成氧化铜纳米粒子 (TE-CuONPs).
- 使用Box-Behnken设计优化合成过程,用于可复制纳米粒子生产.
- 评估合成的TE-CuONP的协同抗微生物和抗癌活性.
主要方法:
- 在HPLC分析中,在Thymus vulgaris提取物中发现了关键的植物化学物质 (quercetin,酸,酸).
- Box-Behnken优化确定了关键的合成参数 (酸铜度,化时间).
- 鉴定包括TEM,XRD,FTIR和DLS;进行了抗菌试验 (MIC,MBC,生物膜抑制,时间杀伤动力学) 和抗癌试验 (抗增殖,亡诱导).
主要成果:
- 优化的TE-CuONP是单分散的,球形的 (19-25nm) 和晶体的 (单临床CuO阶段).
- TE-CuONPs显示出对格拉姆阳性和格拉姆阴性细菌的显著杀菌活性,并抑制了生物膜的形成.
- 观察到与 جنت米辛的协同效应,降低所需剂量并加速细菌根除.
- TE-CuONPs对MCF-7乳腺癌细胞表现出中度的抗增殖活性,诱导了亡.
- 抗氧化能力明显高于原始植物提取物.
结论:
- 可以实现来自Thymus vulgaris的氧化铜纳米颗粒的可重复绿色合成.
- TE-CuONP具有显著的协同抗微生物和抗癌潜力.
- 这项研究强调了植物介导的纳米医学的传染病和癌症治疗的翻译承诺.
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