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两种分片方法对埃塞俄比亚西北部护士的体重减轻和体重均性的比较
Temesgen Ashagrie1, Abrham Tesfaye Habteyes2, Fekadeselassie Teferi Mekonen3
1Menelik II Medical and Health Science College, City Administration of Addis Ababa Health Bureau, Addis Ababa, Ethiopia.
Scientific reports
|February 10, 2026
概括
与使用分片机相比,手工分片片导致较少的质量损失和体重变化. 这两种方法都显示出差异性,但手工分割更好地符合FDA和USP重量均性标准.
科学领域:
- 制药科学 制药科学
- 临床药房实践 临床药房实践
- 药物复杂化药物复杂化
背景情况:
- 分解药片是临床环境中剂量调整的常见做法.
- 关于不同分片方法的准确性存在有限的研究,特别是在埃塞俄比亚.
- 准确的分片对于患者的安全性和治疗疗效至关重要.
研究的目的:
- 为了比较手工分割与平板电脑分割器方法对平板电脑质量损失和重量均性的影响.
- 为了评估遵守FDA和USP指导方针的药片分割准确度.
- 在临床环境中确定最可靠的分片技术.
主要方法:
- 五种不同的平板药物被选择用于研究.
- 使用两种方法将平板分成两部分:手动分手和平板分离器装置.
- 使用描述性统计数据 (Microsoft Excel,SPSS v.25) 测量和分析体重减轻和体重变化.
- 结果与FDA和USP一般章节的接受标准进行了比较.
主要成果:
- 只有60%的手工分割片和20%的分割片符合FDA减肥标准 (<3%).
- 60%的手工分割片超过了USP重量统一性基准 (RSD% < 6),而80%的分割片达到这一标准.
- 与手工分割的药片相比,用分割器分割的药片显示出更大的身高和体重变化.
- 尽管这两种方法都存在差异,但手工分割显示总体质量损失较低,重量变化也比平板分割器要小.
结论:
- 这两种分片方法都带来了质量损失和体重变化.
- 手工分割导致较低的质量损失和更少的变异性,更好地与FDA和USP对这些参数的基准保持一致.
- 需要进一步的研究来优化分片技术,以提高剂量准确性和患者安全.
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