刺激性肠综合征和心理痛苦之间的双向关联:一项基于人口的纵向研究
Ya-Ju Yu1, Yao-Ching Huang2, Tsu-Hsuan Weng3
1Graduate Institute of Life Sciences, College of Biomedical Sciences, National Defense Medical University, Taiwan.
Psychological medicine
|February 10, 2026
概括
刺激性肠综合征 (IBS) 和抑郁和焦虑等心理困扰显示出强烈的双向联系. 睡眠障碍显著恶化了这两个方向的肠-大脑连接.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 微生物组研究的研究.
背景情况:
- 刺激性肠综合征 (IBS) 经常与抑郁和焦虑同时发生.
- 对于IBS和心理困扰之间的双向关系还没有很好地理解.
- 肠-大脑-微生物群轴的失调是一种潜在的共享机制.
研究的目的:
- 调查IBS和心理痛苦之间的时间和双向关联.
- 探索肠-大脑-微生物群轴在这种关系中的作用.
主要方法:
- 两项以人口为基础的回顾性队列研究 (2000-2015年) 使用台湾国家医疗保险研究数据库.
- 队列1:在新诊断为抑郁症/焦虑症的患者中评估IBS风险.
- 队列2:在新诊断IBS的患者中评估抑郁/焦虑风险.
- 统计分析包括倾向得分匹配,多变量考克斯回归和细灰竞争风险模型.
主要成果:
- IBS诊断增加了抑郁症 (aHR=1.55) 和焦虑症 (aHR=1.68) 的风险.
- 抑郁症和焦虑症诊断增加了发展IBS的风险 (分别为aHR=1.45和1.51).
- 在女性和年轻人 (18-39岁) 中,相关性更强.
- 睡眠障碍在两个方向上显著改变了相关性 (子分布HR ≈1.60).
结论:
- 在IBS和心理痛苦之间存在强大的双向关联.
- 研究结果支持综合查和多学科治疗肠-大脑相互作用.
- 这凸显了解决胃肠道和心理健康问题的重要性.
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