在癌症治疗后发生瘤紧急情况的患者中,血小板缩和出血
Le Tian1, Jia-Xin Huang1, Xi Zhang1
1Department of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cancer medicine
|February 10, 2026
概括
癌症治疗诱导的血小板缺血 (CTIT) 影响13.5%的急诊瘤患者. 发烧和多流是CTIT相关出血的关键风险因素,需要提高临床警.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 紧急医疗 紧急医疗
背景情况:
- 癌症治疗诱导的血小板缺血 (CTIT) 是一个显著的并发症.
- 有限的数据存在CTIT相关的出血风险因素在紧急瘤患者,特别是来自中国.
研究的目的:
- 研究中国急诊瘤患者中CTIT和相关器官出血的发生率和危险因素.
- 为了确定CTIT相关出血的预测因素.
主要方法:
- 对8590次急诊瘤诊所的回顾性研究.
- 对1164名CTIT患者的临床特征和结果的分析.
- 确定CTIT和出血的独立风险因素.
主要成果:
- 在13.5%的患者中发生CTIT (1164/8590).
- 在5.24%的CTIT病例中观察到器官出血 (61/1164).
- 对CTIT恶化的独立风险因素包括ECOG评分2-4,第四阶段恶性瘤,器官出血,贫血和发烧.
- 与CTIT相关的出血的独立风险因素是发烧 (OR=4.886) 和多叶流液 (OR=4.812).
- 在出血病例中,肺癌是最常见的恶性瘤 (41%).
结论:
- 导致血小板数量减少的恶性瘤,加上特定的危险因素,需要对出血给予更高的临床关注.
- 发烧和胸腔溢出是预测CTIT患者出血风险的关键指标.
相关概念视频
Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
Emerging Adulthood
725
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
725
Bleeding in Fresh Concrete
616
Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
616
Introduction Cardiac Emergencies
379
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
379
Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K


