相关实验视频
Updated: Feb 12, 2026

09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
3.6K
基于脑肠轴的治疗在长期COVID和ME/CFS的潜在应用:基于病例的系统性审查
Do-Young Kim1,2, Jaeyoung Youn1, Naeun Kang2
1Department of Acupuncture & Moxibustion, Jaseng Korean Medicine Hospital, Seoul, 06110, Republic of Korea.
Journal of translational medicine
|February 10, 2026
概括
基于电的阴道刺激显示出治疗肌痛性脑炎/慢性疲劳综合征 (ME/CFS) 和长期COVID疲劳的前景. 肠道微生物组和神经刺激干预可以通过准脑肠轴来改善症状.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 和长期COVID共享诸如疲劳,运动后不适 (PEM) 和胃肠道问题等症状.
- 脑肠轴失调,包括失调和神经炎症,与ME/CFS和长期COVID有关.
- 目前针对这些途径的治疗策略尚未明确定义.
研究的目的:
- 评估基于电 (EA) 的深神经刺激在治疗COVID后ME/CFS时的疗效.
- 对针对ME/CFS和长期COVID的脑肠轴干预的随机对照试验 (RCT) 进行系统审查.
主要方法:
- 分析了一例COVID后的ME/CFS病例,该病例接受了基于EA的深神经刺激治疗.
- 对8个RCT (790名参与者) 进行了系统审查,检查了肠道微生物组和神经刺激干预措施.
主要成果:
- 患者经历了显著的疲劳减轻,精神疲劳和动力最初有所改善.
- 协生和草药疗法改善了疲劳/PEM,改变了肠道细菌/中枢神经系统代谢.
- 神经刺激,特别是运动的tDCS,显示出好处,而其他方法的有效性有限.
结论:
- 脑肠轴干预可以通过调节神经炎症和肠道微生物群来缓解ME/CFS和长期COVID的疲劳.
- 基于EA的阴道刺激是严重或耐治疗病例的潜在选择.
- 为了优化治疗策略,需要进一步进行大规模的机制研究和RCT.
相关概念视频
Hypothalamic-Pituitary Axis
66.5K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.5K
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.6K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Lewis Acids and Bases
48.5K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.5K
Weak Base Solutions
25.4K
Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
25.4K
Base Excision Repair
26.4K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
The first step of...
26.4K

