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Updated: Feb 12, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

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由于衰老引起的 B 细胞降低,可以通过 ROS 激活的 Fos/CCL3 信号通路增强骨髓巨细胞的骨质细胞生成

Ruiqing Sun1, Lan Luo1, Yang Chen1

  • 1Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China.

Immunity & ageing : I & A
|February 11, 2026
PubMed
概括

在老年骨质疏松症中,氧化应激加速了B淋巴细胞的免疫衰老,减少了原始B细胞. 这激活了一条促进骨再吸收骨质细胞形成的途径,建议CCR1抗剂作为治疗点.

关键词:
在Fos/CCL3信号通路中.免疫衰老 - 免疫衰老巨细胞是一个巨细胞.原始 B 细胞是 B 细胞的原始细胞.这就是ROSOS ROS.年老骨质疏松症的老年骨质疏松症

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