高清跨直流刺激与中风患者上肢功能的数字康复相结合的高清跨直流刺激的有效性和安全性:随机,双盲,假控确认试验的研究方案
Jinuk Kim1, Su-Hyun Lee1, Eunmi Kim1
1Department of Physical and Rehabilitation Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea.
Trials
|February 11, 2026
概括
这项研究研究了高清超直流刺激 (HD-tDCS) 与数字康复相结合,以改善中风后上肢功能. 这些发现旨在增强神经可塑性,并指导精确的神经康复策略.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 神经调节是一种神经调节.
背景情况:
- 脑卒中是导致长期残疾的主要原因,通常导致上肢持续损伤.
- 传统的康复治疗可能无法完全恢复中风幸存者的运动功能.
- 高清度跨直流刺激 (HD-tDCS) 提供精确的皮质向,以提高潜在的运动恢复.
研究的目的:
- 确认HD-tDCS与数字上肢康复相结合的有效性和安全性.
- 在慢性中风幸存者中改善上肢运动功能.
- 探索HD-tDCS增强恢复背后的神经可塑性机制.
主要方法:
- 一个多中心的,随机的,双盲的,假控制的试验,涉及64名慢性单边中风的参与者.
- 干预:在4周内进行10次会议,将HD-tDCS (针对M1和aIPS) 与数字上肢康复相结合.
- 结果指标包括Fugl-Meyer评估,抓地力,性测试和通过fNIRS进行皮质激活.
主要成果:
- 该研究旨在严格评估对干预的行为和血液动力学反应.
- 探索性发现表明HD-tDCS有潜力增强运动恢复.
- 功能近红外光谱学 (fNIRS) 将描述与运动改善相关的与任务相关的血液动力学反应.
结论:
- 这项试验为HD-tDCS与数字康复相结合提供了有希望的探索性研究结果.
- 它的目的是为HD-tDCS增强的神经可塑性的机制提供证据.
- 结果将为未来对中风幸存者的精确神经康复策略的开发提供信息.
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