孕产妇补充以反保护的阿尔金因,重塑阴茎微生物组,并增强新生儿羔羊的生长
Xiangjian Peng1, Yuyang Xue1, Hailiang Wang1
1College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, 832000, China.
Animal microbiome
|February 11, 2026
概括
在母羊中补充流血保护的L-氨酸 (RP-Arg) 通过增加乳母IGF-1和乳酸来增强羊羔的生长. 这种营养策略也对乳腺微生物群和肝脏代谢产生积极影响,改善羔羊的发育.
科学领域:
- 动物营养 动物营养
- 生殖生理学 生殖生理学
- 微生物组研究 微生物组研究
背景情况:
- 孕期和哺乳期的母羊的营养对于羔羊的生长至关重要.
- 血保护的L-氨酸 (RP-Arg) 诱导了母体的代谢适应,但其对羔羊的持续影响尚不清楚.
- 这项研究调查了RP-Arg对羔羊生长,免疫功能和肠-肝-微生物组轴的影响.
研究的目的:
- 评估RP-Arg在母羊中食补充剂对其羔羊生长表现和生理参数的影响.
- 用RP-Arg补充的母羊羔的乳房微生物群和肝脏代谢概况的特征.
- 探索由母亲RP-Arg补充剂影响的肠肝代谢相互作用.
主要方法:
- 27只中国美利诺羊被分配到只放牧 (CON),放牧加缩料 (SF) 或SF加RP-Arg (ARG) 的饮食中.
- 羊羔14天大时采集羊皮皮和肝脏组织进行分析.
- 使用16S rRNA测序分析了叶微生物群,并通过非向的代谢学检查了肝脏代谢.
主要成果:
- SF和ARG组的羔羊表现出更好的早期生长;ARG组的平均每日增长和总体重增长高于SF组.
- 补充RP-Arg增加了乳母乳酸和类似胰岛素的生长因子-1 (IGF-1) 度.
- ARG组表现出较高的状细菌Bacteroidota和Prevotella的相对丰度,以及肝脏代谢的改变,包括调高的阿尔金因-蛋白代谢.
结论:
- 在母羊中补充RP-Arg可提高胆乳糖IGF-1和乳酸,丰富特定的乳腺细菌,并重编程羊羔的肝脏代谢.
- 这些变化与早期羔羊生长率的提高有关.
- 这项研究表明,由母亲的RP-Arg补充剂介导的有益的肠肝代谢相互作用会影响羔羊的发育.
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