发现家庭结核病感染检测和护理模式,使用一种新的生物信息学链接战略
Jeffrey I Campbell1, Meredith B Brooks2, Jenine Dankovchik3
1Section of Pediatric Infectious Diseases, Department of Pediatrics, Boston Medical Center, Boston, USA.
大多数家庭成员缺乏结核病 (TB) 检测,即使在哨戒患者的检测结果呈阳性之后. 然而,家庭环境对于识别和治疗潜伏结核病感染至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 结核病研究 结核病研究
背景情况:
- 家庭是结核病 (TB) 活跃病例发现的关键.
- 有限的数据存在于没有已知的传染病例的家庭内潜伏结核病感染集群.
- 了解家庭动态对于结核病感染治疗级联进展至关重要.
研究的目的:
- 为了调查家庭中潜在的结核病感染集群.
- 分析家庭成员之间的结核病感染护理级联进展.
- 确定家庭接触者测试,阳性和治疗的预测因素.
主要方法:
- 利用美国社区卫生中心网络 (2014-2022) 的数据.
- 确定的哨戒患者具有阳性结核病检测 (TST或IGRA).
- 将哨兵患者与家庭成员联系起来,并分析了测试,阳性和治疗率.
主要成果:
- 35,772名与129,432名家庭成员相关的哨戒患者.
- 26.1%的家庭成员进行了测试;9.3%的测试结果呈阳性.
- 治疗被规定给20.6%的阳性家庭成员;哨戒患者治疗影响了结果.
结论:
- 在家庭成员的结核病感染测试中存在重大差距.
- 家庭和患者特征影响测试,阳性和治疗.
- 家庭代表着对结核病感染的识别和治疗未充分利用的环境,即使没有活跃的结核病.
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