在动物模型中对乙基暴露的神经系统影响的系统性审查
Laura V Dishaw1, Michele M Taylor2, Deborah Segal1
1Office of Research and Development, Center for Public Health and Environmental Assessment, US EPA.
概括
这次审查发现,乙 (EB) 影响动物神经系统的证据有限. 虽然一些研究表明听力和耳毛细胞的影响,但其他神经毒性结果仍然没有确定性.
科学领域:
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
- 环境健康 环境健康
背景情况:
- 乙 (EB) 是一种产量大的化学物质,对工业工人和污染附近的社区有潜在的暴露风险.
- 了解EB的神经毒性潜力对于公共卫生风险评估至关重要.
研究的目的:
- 系统地审查动物证据,以乙暴露对神经系统的影响.
- 综合关于听觉效应,神经递质,神经行为和大脑形态学的发现.
主要方法:
- 一项全面的文献搜索确定了9679项研究,其中21项动物毒理学研究符合PECO标准.
- 包括的研究在数据提取和合成之前评估了偏差风险和敏感性.
- 评估结果包括听觉功能,神经递质水平,神经行为测试和大脑体重/组织病理学.
主要成果:
- 六项研究 (中/低置信度) 表明对耳毛细胞和听力值有一致的,剂量和持续时间相关的影响.
- 对神经递质和神经行为影响的证据被评为低信心和不一致.
- 相对的大脑体重变化不一致;绝对的大脑体重和组织病理学显示没有变化.
结论:
- 动物暴露在乙中显示出对听觉系统影响的一致证据.
- 其他神经系统终点,包括神经行为和神经递质,缺乏足够的一致证据来得出结论.
- 需要进一步进行高质量的研究,以澄清乙基的全部神经毒理学特征.
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