营养状况对肝硬化和腹出血患者的凝血和炎症的影响
Tian Yindi1, Wang Mincong2, Jia Hui2
1Department of Infectious Diseases, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
概括
在肝硬化和水出血患者中,营养不良很普遍,影响了结果. 使用控制营养状况 (CONUT) 评分进行早期营养评估对于管理这些患者至关重要.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 临床营养学 临床营养学
- 内部医学 内部医学
背景情况:
- 营养不良是肝硬化和急性水出血患者的重要并发症.
- 门高血压有助于改变这些患者的营养状况.
- 控制营养状况 (CONUT) 评分是评估营养不良和预测结果的有效工具.
研究的目的:
- 通过使用CONUT评分来评估患有肝硬化食道胃水出血 (EVB) 的患者的营养状况.
- 为了研究营养状况,凝血参数和炎症标志物之间的关联,在患有肝硬化EVB的患者.
主要方法:
- 对151名肝硬化EVB患者的临床数据进行了回顾性分析.
- 用CONUT评分来评估营养状况.
- 使用一般线性模型分析来探索营养,凝血和炎症指数之间的相关性.
主要成果:
- 观察到营养不良的高患病率,81.5%的患者表现出中度至严重的营养不良,基于CONUT得分.
- 发现了显著的凝血障碍,包括延长的前热血素时间 (PT),国际正常化比率 (INR) 和升高的D-二次体.
- 炎症标志物如IL-6的升高与营养不良显著相关.
- CONUT分数与PT,INR和IL-6正相关,与前热血素活性 (PTA) 负相关.
结论:
- 中度至重度的营养不良在患有肝硬化EVB的患者中非常普遍.
- 营养不良在这个患者群体中独立地与凝血功能障碍和全身炎症有关.
- 加强营养监测和量身定制的干预措施对于改善肝炎EVB患者的预后至关重要.
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