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Updated: Feb 12, 2026

Stereocilia Bundle Imaging with Nanoscale Resolution in Live Mammalian Auditory Hair Cells
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Stereocilia Bundle Imaging with Nanoscale Resolution in Live Mammalian Auditory Hair Cells

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프로토卡德林15 - LHFPL5尖端链接复合体是毛细胞立体纤维中的异构四基组件

Sarah Clark1, Jaba Mitra2, Johannes Elferich1

  • 1Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Biophysical journal
|February 11, 2026
PubMed
概括

研究人员开发了敏感的单分子测试,以量化内耳中的机械传感转导 (MT) 复杂蛋白质. 这些方法揭示了PCDH15和LHFPL5等关键子单元的固体几何学,进步了我们对听觉和平衡机制的理解.

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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