在全身性硬化症中量化肠道脑相互作用疾病的患病率
Kate Seaton1, Alannah Quinlivan2,3, Nava Ferdowsi3
1Department of General Medicine, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
Neurogastroenterology and motility
|February 11, 2026
概括
系统性硬化症患者经常经历肠-大脑相互作用障碍,影响他们的胃肠健康和生活质量. 识别这些疾病对于管理SSc相关的胃肠道疾病至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 自免疫性疾病 自免疫性疾病
- 神经胃肠病学 神经胃肠病学
背景情况:
- 系统性硬化症 (SSc) 是一种罕见的自身免疫性疾病,常常表现为胃肠动.
- 肠-大脑轴中断在SSc相关的胃肠道症状中的作用尚不清楚.
研究的目的:
- 为了确定肠-大脑相互作用 (DGBI) 疾病的患病率,在患有系统性硬化症的患者中出现类似症状.
- 调查DGBI症状与SSc严重程度,日常功能和生活质量之间的关联.
主要方法:
- 一项横截面调查评估了罗马-IV标准的刺激性肠综合征 (IBS),功能性消化不良 (FD),功能性消化不良和食后困扰综合征 (PPDS).
- 经过验证的问卷 (SF-36,HAQ-DI,UCLA GIT 2.0,ScleroID) 评估了生活质量,功能和疾病影响.
- 线性回归分析了DGBI症状和临床参数之间的关联.
主要成果:
- 在101名SSc患者中,21人符合FD标准,18人符合IBS标准.
- IBS和FD与更严重的SSc胃肠道疾病 (GIT 2.0分数) 有显著的关联.
- FD与较差的身体生活质量相关 (SF-36 PCS),IBS和FD都与更大的整体SSc影响 (ScleroID) 有关.
结论:
- 大约五分之一的接受调查的SSc患者符合DGBI类症状的诊断标准.
- 在评估SSc胃肠道疾病时,应考虑肠-大脑相互作用的障碍.
- 一部分SSc患者可能会出现同时存在的DGBI症状,这些症状有助于他们的整体临床表现.
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