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相关概念视频

Acid Strength and Molecular Structure03:05

Acid Strength and Molecular Structure

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Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
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Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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Molecular Structure and Acidity02:34

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An acid can be deprotonated to form a conjugate base or an anion. If the produced anion is more stable, then the acid is stronger. On the contrary, if the anion is unstable, then the acid is weaker. Hence, to determine the acidity of the compound, the stability of its conjugate base is studied using various factors.
The size effect explains the change in atomic size on acidity. When comparing the acids formed from elements that belong to the same column in the periodic table, their atomic sizes...
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Structures of Carboxylic Acid Derivatives

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Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
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Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
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用于结构探索的多糖酸自动组装.

Sandhya N Mardhekar1, Dominik Weh1,2, Martina Delbianco1

  • 1Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.

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此摘要是机器生成的。

研究人员使用自动化甘氨酸组装精确合成了多糖酸 (PGA) 寡合体. 这些明确的模型揭示了结合的洞察力,并为开发新型糖原材料提供了框架.

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科学领域:

  • 生物聚合物合成的方法
  • 碳水化合物的化学成分
  • 材料科学是一种材料科学.

背景情况:

  • 聚氨酸酸是重要的海洋生物聚合物,涉及至关重要的生物过程.
  • 它们的结构异质性使理解结构-功能关系变得复杂.

研究的目的:

  • 开发一种精确合成定义的多糖酸 (PGA) 寡合物的方法.
  • 研究这些合成的寡合物的结构和功能性质,特别是结合.

主要方法:

  • 自动化甘氨酸组件 (AGA) 用于合成β-(1-4) 结合的d-葡萄糖酸 (GlcA) 寡合体.
  • 分子动力学模拟来分析寡合体的结构和灵活性.
  • 进行NMR定位以研究结合相互作用.

主要成果:

  • 通过控制链长度和立体化学,成功合成了 GlcA 寡合体.
  • 模拟显示了双重螺旋形状,在短小分子中具有刚性,在长小分子中具有灵活性.
  • 核磁共振显示了分散的静电结合,而不是局部化.

结论:

  • 定义的PGA寡合体作为研究离子相互作用的有价值的分子模型.
  • 这项工作为设计具有量身定制性质的先进尿酸基糖材料提供了基础.